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Light‐Induced PEGylation and Functionalization of Semiconductor Polymer Dots
Author(s) -
Chen Haobin,
Zhou Hua,
Men Xiaoju,
Sun Kai,
Sun Zezhou,
Fang Xiaofeng,
Wu Changfeng
Publication year - 2017
Publication title -
chemnanomat
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.947
H-Index - 32
ISSN - 2199-692X
DOI - 10.1002/cnma.201700140
Subject(s) - bioconjugation , pegylation , surface modification , oxetane , polymer , polyethylene glycol , covalent bond , peg ratio , nanoparticle , chemistry , molecule , side chain , nanotechnology , materials science , combinatorial chemistry , polymer chemistry , organic chemistry , finance , economics
A semiconductor polymer with side‐chain oxetane groups was synthesized to form highly fluorescent, functionalized, and ultra‐stable polymer dots (Pdots). A facile light‐induced strategy covalently links functional polyethylene glycol (PEG) molecules to polymer dots while simultaneously providing functional groups for bioconjugation. The influence of photo‐crosslinkable side‐chains and PEG molecules on the properties and performance of Pdots was systematically investigated. The Pdots functionalized by photo‐crosslinking show specific labeling and negligible non‐specific binding as compared to non‐functionalized Pdots. The results provide a viable strategy for nanoparticle assembly and functionalization.