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Progress in Biomedical Applications of Functionalized Nucleic Acid Nanodevices (NANDs)
Author(s) -
Wu Guangqi,
Lu Hua
Publication year - 2016
Publication title -
chemnanomat
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.947
H-Index - 32
ISSN - 2199-692X
DOI - 10.1002/cnma.201600036
Subject(s) - nucleic acid , nanotechnology , internalization , dna , materials science , chemistry , computational biology , biology , biochemistry , cell
DNA and RNA are building blocks with excellent programmability for nanoscale assembly. Owing to their appealing properties such as precision in bottom‐up fabrication, enhanced stability and cellular internalization, designed nucleic acid nanodevices (NANDs) have been widely explored in biomedical research. Compared with pristine nucleic acids, chemically modified NANDs exhibit a wider spectrum of applicability. In this Focus Review, we highlight recent advances of NANDs functionalized with small molecules, peptides/proteins or inorganic materials, and elucidate their promising future for biomedical application.