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Affinity of Glycan‐Modified Nanodiamonds towards Lectins and Uropathogenic Escherichia Coli
Author(s) -
Turcheniuk Volodymyr,
Turcheniuk Kostiantyn,
Bouckaert Julie,
Barras Alexandre,
Dumych Tetiana,
Bilyy Rostyslav,
Zaitsev Vladimir,
Siriwardena Aloysius,
Wang Qi,
Boukherroub Rabah,
Szunerits Sabine
Publication year - 2016
Publication title -
chemnanomat
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.947
H-Index - 32
ISSN - 2199-692X
DOI - 10.1002/cnma.201500229
Subject(s) - glycan , escherichia coli , monosaccharide , chemistry , lectin , biochemistry , mannan , biophysics , polysaccharide , biology , glycoprotein , gene
Nanodiamond particles (NDs) modified with glycan ligands are revealing themselves to have great promise as new nanomaterials for combating biofilm formation and as promising anti‐adhesive scaffolds. Currently, the strategies at hand to formulate glycan‐modified NDs (glyco‐NDs) are limited to a few reports. We demonstrate herein that the photoinduced covalent attachment of unmodified sugars results in glyco‐NDs with high binding affinity to lectins and a uropathogenic Escherichia coli strain ( E. coli UTI89). While the binding affinities of glyco‐NDs to different lectins is partially sacrificed when monosaccharides such as mannose are photochemically integrated onto NDs, in the case of disaccharides and oligosaccharides the binding affinity of glyco‐NDs to lectins is preserved. Moreover, mannan‐modified NDs show strong interactions with uropathogenic E. coli ., suggesting the effectiveness of photochemically formed glyco‐NDs for disruption of E. coli ‐mediated biofilms.