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Numerical studies of hemodynamic alterations in pre‐ and post‐stenting cerebral aneurysms using a multiscale modeling
Author(s) -
Yu Hongtao,
Huang George P.,
Yang Zifeng,
Ludwig Bryan R.
Publication year - 2019
Publication title -
international journal for numerical methods in biomedical engineering
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.741
H-Index - 63
eISSN - 2040-7947
pISSN - 2040-7939
DOI - 10.1002/cnm.3256
Subject(s) - hemodynamics , cardiology , medicine , computer science
The aim of this work was to use a multiscale modeling to study the influence of stent deployment, with generic stents, on flow distributions within the vascular network and the hemodynamic alterations within the cerebral aneurysms pre‐ and post‐stenting. To achieve this goal, two image‐based anatomical cerebral aneurysm models were reconstructed along with the respective aneurysms post‐stenting models after deploying a 16‐ or 24‐wire stent. The investigation results revealed that the stent may increase the local pressure resistance resulting in flow alterations. The hemodynamic parameters demonstrated stent placement can reduce the intra‐aneurysmal pressure, decrease wall shear stress (WSS) at the neck region, and increase blood turnover time for aneurysm case I (sidewall aneurysm). These findings are consistent with the trends of hemodynamic changes reported previously. However, aneurysm case II (bifurcation aneurysm) showed gradually increased intra‐aneurysmal pressure and the pressure at the neck region, decreased WSS over the sac surface, and enhanced flow vortices within the aneurysm. When simulating the hemodynamics of pre‐ and post‐stenting aneurysms for a patient using measured flow waveforms, the flow alteration induced by the stent deployment may affect the hemodynamic predictions for the post‐stenting aneurysm. Thus, the remeasurement of boundary conditions once the morphology of the aneurysm is deformed is needed in follow‐up studies with a focus on aneurysm growth and stent deployment.