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A surrogate mechanostatistical microstructural model to inform whole hip cortical bone remodelling
Author(s) -
Wang Xiaoming,
Das Raj,
Fernandez Justin
Publication year - 2019
Publication title -
international journal for numerical methods in biomedical engineering
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.741
H-Index - 63
eISSN - 2040-7947
pISSN - 2040-7939
DOI - 10.1002/cnm.3183
Subject(s) - bone remodeling , cortical bone , computer science , bone histomorphometry , biomedical engineering , materials science , trabecular bone , anatomy , medicine , pathology , osteoporosis
Multiscale models of bone remodelling which incorporate clinically important features at a wide range of spatial scales are computationally intractable. In addition, there is a large gap in existing bone remodelling literature which deals with Haversian‐level cortical bone remodelling behaviour and its effect on whole organ bone strength. In this study, we present an integration between continuum mechanics and surrogate modelling as an efficient circumvention to the problem of intractability, linked with an intricate 3D cortical bone remodelling algorithm which captures realistic microanatomical features at the Haversian level. The surrogate model predicted clear differentiation in long‐term bone strength changes in clinically significant cases with extremely high computational efficiency.