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Simulation of actin distribution of osteoblasts on titanium pillar arrays using a bio‐chemo‐mechanical model
Author(s) -
Truong D.,
Bahls C. R.,
Nebe B.,
Rienen U.
Publication year - 2018
Publication title -
international journal for numerical methods in biomedical engineering
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.741
H-Index - 63
eISSN - 2040-7947
pISSN - 2040-7939
DOI - 10.1002/cnm.3097
Subject(s) - adhesion , pillar , titanium , materials science , substrate (aquarium) , actin , function (biology) , cell adhesion , nanotechnology , composite material , structural engineering , metallurgy , engineering , microbiology and biotechnology , geology , biology , oceanography
A numerical model for the adhesion of osteoblasts on titanium micropillar structures is suggested, and a function representing the concentration level of the adhesion on the pillars is constructed based on experimental observation. The introduction of this function helps a well‐known bio‐chemo‐mechanical model to better predict the formation of actin in osteoblasts when they are laid on arrays of titanium micro‐pillars of various size attached to silicon substrate. A parameter study suggests that each pillar is associated with a different pattern of adhesion. Our finding emphasises a capability of the bio‐chemo‐mechanical model that it can well explain the strong influence of the boundary condition on the formation of actin within the cells.