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A computational modeling of blood flow in asymmetrically bifurcating microvessels and its experimental validation
Author(s) -
Lee TaeRin,
Hong JiAh,
Yoo Sung Sic,
Kim Do Wan
Publication year - 2018
Publication title -
international journal for numerical methods in biomedical engineering
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.741
H-Index - 63
eISSN - 2040-7947
pISSN - 2040-7939
DOI - 10.1002/cnm.2981
Subject(s) - hagen–poiseuille equation , blood flow , hematocrit , microcirculation , mechanics , flow (mathematics) , computational model , simulation , computer science , geometry , physics , mathematics , medicine , cardiology , radiology , endocrinology
Microvascular transport is complex due to its heterogeneity. Many researchers have been developing mathematical and computational models in predicting microvascular geometries and blood transport. However, previous works were focused on developing simulation models, not on validating suggested models with microvascular geometry and blood flow in the real microvasculature. In this paper, we suggest a computational model for microvascular transport with experimental validation in its geometry and blood flow. The geometry is generated by controlling asymmetric conditions of microvascular network. Also, the blood flow in microvascular networks is predicted by considering in vivo viscosity, Poiseuille flow model, and hematocrit redistribution by plasma skimming. The suggested model is validated by the measured data in rat mesentery. Also, the microvascular transport in a case of mouse cortex is predicted and compared against experimental data to check applicability of the suggested model.