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A regulated multiscale closed‐loop cardiovascular model, with applications to hemorrhage and hypertension
Author(s) -
Canuto Daniel,
Chong Kwitae,
Bowles Cayley,
Dutson Erik P.,
Eldredge Jeff D.,
Benharash Peyman
Publication year - 2018
Publication title -
international journal for numerical methods in biomedical engineering
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.741
H-Index - 63
eISSN - 2040-7947
pISSN - 2040-7939
DOI - 10.1002/cnm.2975
Subject(s) - baroreflex , cardiology , medicine , circulatory system , contractility , peripheral , sympathetic nervous system , heart rate , autonomic nervous system , blood pressure
Abstract A computational tool is developed for simulating the dynamic response of the human cardiovascular system to various stressors and injuries. The tool couples 0‐dimensional models of the heart, pulmonary vasculature, and peripheral vasculature to 1‐dimensional models of the major systemic arteries. To simulate autonomic response, this multiscale circulatory model is integrated with a feedback model of the baroreflex, allowing control of heart rate, cardiac contractility, and peripheral impedance. The performance of the tool is demonstrated in 2 scenarios: neurogenic hypertension by sustained stimulation of the sympathetic nervous system and an acute 10% hemorrhage from the left femoral artery.