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The study of the function of AQP4 in cerebral ischaemia–reperfusion injury using poroelastic theory
Author(s) -
Mokhtarudin Mohd Jamil Mohamed,
Payne Stephen J.
Publication year - 2017
Publication title -
international journal for numerical methods in biomedical engineering
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.741
H-Index - 63
eISSN - 2040-7947
pISSN - 2040-7939
DOI - 10.1002/cnm.2784
Subject(s) - astrocyte , poromechanics , ischemia , aquaporin 4 , extracellular fluid , brain ischemia , reperfusion injury , medicine , chemistry , neuroscience , extracellular , pathology , central nervous system , biology , biochemistry , porous medium , organic chemistry , porosity
Summary Brain oedema is thought to form and to clear through the use of water‐protein channels, aquaporin‐4 (AQP4), which are found in the astrocyte endfeet. The model developed here is used to study the function of AQP4 in the formation and elimination of oedema fluid in ischaemia–reperfusion injury. The cerebral space is assumed to be made of four fluid compartments: astrocyte, neuron, ECS and blood microvessels, and a solid matrix for the tissue, and this is modelled using multiple‐network poroelastic theory. AQP4 allows the movement of water between astrocyte and the ECS and the microvessels. It is found that the presence of AQP4 may help in reducing vasogenic oedema shown by a decrease in brain tissue extracellular pressure. However, the astrocyte pressure will increase to compensate for this decrease, which may lead to cytotoxic oedema. In addition, the swelling will also depend on the ionic concentrations in the astrocyte and extracellular space, which may change after ischaemic stroke. Understanding the role of AQP4 in oedema may thus help the development of a treatment plan in reducing brain swelling after ischaemia–reperfusion