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Modeling cytokinesis of eukaryotic cells driven by the actomyosin contractile ring
Author(s) -
Zhao Jia,
Wang Qi
Publication year - 2016
Publication title -
international journal for numerical methods in biomedical engineering
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.741
H-Index - 63
eISSN - 2040-7947
pISSN - 2040-7939
DOI - 10.1002/cnm.2774
Subject(s) - cytokinesis , eukaryotic cell , cell division , ring (chemistry) , biophysics , cell cortex , division (mathematics) , cortex (anatomy) , microbiology and biotechnology , physics , chemistry , cell , biological system , mechanics , biology , cytoskeleton , mathematics , neuroscience , biochemistry , arithmetic , organic chemistry
Summary A three‐dimensional (3D) hydrodynamic model for cytokinesis of eukaryotic cells is developed, in which we model dynamics of actomyosins in the cell cortex, in particular, along the cytokinetic ring formed in the cortex and in the neighborhood of the cell's division plane explicitly. Specifically, the active force actuated by the actomyosin's activity along the cytokinetic ring is modeled by a surface force whose strength is proportional to the actomyosin concentration while the cell morphology is tracked by a phase field model. The model is then solved in 3D space and time using a finite difference method on graphic processing units. Dynamical morphological patterns of eukaryotic cells during cytokinesis are numerically simulated with the model. These simulated morphological patterns agree quantitatively with experimental observations. Copyright © 2016 John Wiley & Sons, Ltd.