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An integrated mathematical model of the cardiovascular and respiratory systems
Author(s) -
Trenhago Paulo Roberto,
Fernandes Luciano Gonçalves,
Müller Lucas Omar,
Blanco Pablo Javier,
Feijóo Raúl Antonino
Publication year - 2016
Publication title -
international journal for numerical methods in biomedical engineering
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.741
H-Index - 63
eISSN - 2040-7947
pISSN - 2040-7939
DOI - 10.1002/cnm.2736
Subject(s) - cardiorespiratory fitness , partial pressure , carbon dioxide , oxygen , oxygen transport , hemodynamics , dissociation (chemistry) , chemistry , thermodynamics , mechanics , computer science , cardiology , medicine , physics , organic chemistry
Summary This study presents a lumped model for the human cardiorespiratory system. Specifically, we incorporate a sophisticated gas dissociation and transport system to a fully integrated cardiovascular and pulmonary model. The model provides physiologically consistent predictions in terms of hemodynamic variables such as pressure, flow rate, gas partial pressures, and pH. We perform numerical simulations to evaluate the behavior of the partial pressures of oxygen and carbon dioxide in different vascular and pulmonary compartments. For this, we design the rest condition with low oxygen requirements and carbon dioxide production and exercise conditions with high oxygen demand and carbon dioxide production. Furthermore, model sensitivity to more relevant model parameters is studied. Copyright © 2015 John Wiley & Sons, Ltd.