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Perspective on CFD studies of coronary artery disease lesions and hemodynamics: A review
Author(s) -
Zhang JunMei,
Zhong Liang,
Su Boyang,
Wan Min,
Yap Jinq Shya,
Tham Jasmine P. L.,
Chua Leok Poh,
Ghista Dhanjoo N.,
Tan Ru San
Publication year - 2014
Publication title -
international journal for numerical methods in biomedical engineering
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.741
H-Index - 63
eISSN - 2040-7947
pISSN - 2040-7939
DOI - 10.1002/cnm.2625
Subject(s) - coronary artery disease , hemodynamics , computational fluid dynamics , cad , fractional flow reserve , stenosis , cardiology , medicine , initialization , radiology , computer science , engineering , myocardial infarction , engineering drawing , coronary angiography , aerospace engineering , programming language
SUMMARY Coronary artery disease (CAD) is the most common cardiovascular disease. Early diagnosis of CAD's physiological significance is of utmost importance for guiding individualized risk‐tailored treatment strategies. In this paper, we first review the state‐of‐the‐art clinical diagnostic indices to quantify the severity of CAD and the associated invasive and noninvasive imaging technologies in order to quantify the anatomical parameters of diameter stenosis, area stenosis, and hemodynamic indices of coronary flow reserve and fractional flow reserve. With the development of computational technologies and CFD methods, tremendous progress has been made in applying image‐based CFD simulation techniques to elucidate the effects of hemodynamics in vascular pathophysiology toward the initialization and progression of CAD. So then, we review the advancements of CFD technologies in patient‐specific modeling, involving the development of geometry reconstruction, boundary conditions, and fluid–structure interaction. Next, we review the applications of CFD to stenotic sites, in order to compute their hemodynamic parameters and study the relationship between the hemodynamic conditions and the clinical indices, to thereby assess the amount of viable myocardium and candidacy for percutaneous coronary intervention. Finally, we review the strengths and limitations of current researches of applying CFD to CAD studies. Copyright © 2014 John Wiley & Sons, Ltd.