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Transient stress‐based and strain‐based hemolysis estimation in a simplified blood pump
Author(s) -
Pauli Lutz,
Nam Jaewook,
Pasquali Matteo,
Behr Marek
Publication year - 2013
Publication title -
international journal for numerical methods in biomedical engineering
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.741
H-Index - 63
eISSN - 2040-7947
pISSN - 2040-7939
DOI - 10.1002/cnm.2576
Subject(s) - hemolysis , shear stress , cauchy stress tensor , mechanics , finite element method , strain rate tensor , infinitesimal strain theory , stress (linguistics) , materials science , mathematics , mathematical analysis , physics , structural engineering , engineering , medicine , linguistics , philosophy , immunology
SUMMARY We compare two approaches to numerical estimation of mechanical hemolysis in a simplified blood pump model. The stress‐based model relies on the instantaneous shear stress in the blood flow, whereas the strain‐based model uses an additional tensor equation to relate distortion of red blood cells to a shear stress measure. We use the newly proposed least‐squares finite element method (LSFEM) to prevent negative concentration fields and show a stable and volume preserving LSFEM for the tensor equation. Application of both models to a simplified centrifugal blood pump at three different operating conditions shows that the stress‐based model overestimates the rate of hemolysis. The strain‐based model is found to deliver lower hemolysis rates because it incorporates a more detailed description of biophysical phenomena into the simulation process. Copyright © 2013 John Wiley & Sons, Ltd.