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Numerical investigation of axonal cargo rerouting in a dendrite: A three kinetic state model
Author(s) -
Kuznetsov A. V.
Publication year - 2013
Publication title -
international journal for numerical methods in biomedical engineering
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.741
H-Index - 63
eISSN - 2040-7947
pISSN - 2040-7939
DOI - 10.1002/cnm.2521
Subject(s) - kinesin , dendrite (mathematics) , microtubule , molecular motor , axoplasmic transport , kinetic energy , biophysics , physics , biology , neuroscience , classical mechanics , microbiology and biotechnology , geometry , mathematics
SUMMARY The purpose of this paper is to develop a three‐kinetic state model to investigate axonal cargo rerouting in a dendrite. It is assumed that axonal cargos are transported by kinesin motors; they can enter dendrites riding on plus‐end‐out microtubules (MTs). If this happens, cargos are rerouted by dissociating from these MTs and associating with minus‐end‐out MTs. The same kinesin motors then move axonal cargos out of the dendrite. The model predicts how far axonal cargos can penetrate into the dendrite, concentrations of various populations of axonal cargos, and cargo fluxes. Copyright © 2012 John Wiley & Sons, Ltd.