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Investigation of brain contusion mechanism and threshold by combining finite element analysis with in vivo histology data
Author(s) -
Mao Haojie,
Yang King H.
Publication year - 2011
Publication title -
international journal for numerical methods in biomedical engineering
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.741
H-Index - 63
eISSN - 2040-7947
pISSN - 2040-7939
DOI - 10.1002/cnm.1403
Subject(s) - brain contusion , coronal plane , strain (injury) , materials science , anatomy , traumatic brain injury , biomedical engineering , medicine , psychiatry
A previously validated, highly detailed three‐dimensional finite element (FE) rat brain model was used to correlate FE model‐predicted intracranial responses with experimentally measured brain contusions. In the published in vivo experimental study, the animals were injured via a controlled cortical impact device at two different severities and the location and volume of contusion measured at 24 h post injury. Brain internal responses, including the maximum principal strain (MPS), maximum shear strain (MSS), shear strain (SS) in the coronal plane, strain energy density (SED), and intracranial pressure (ICP), were investigated through FE simulations. Distributions of MPS, MSS, and SED were comparable with the shapes of contusion observed experimentally. However, the regions with high positive ICP were not found to correlate with the regions of brain contusion. Locations of high SS were in the vicinity of the experimental contusion region, but the shallow shape of the SS distribution differed greatly from contusion observed experimentally. This study suggests that MPS, MSS, and SED are candidate injury mechanisms for brain contusion, and the corresponding threshold for predicting the contusion volume measured at 24 h post injury is 0.265 MPS, 0.281 MSS, or 1.72E −5 (J/mm 3 ) SED based on the current FE model. Copyright © 2010 John Wiley & Sons, Ltd.