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Computational model of whole blood exhibiting lateral platelet motion induced by red blood cells
Author(s) -
Crowl Lindsay M.,
Fogelson Aaron L.
Publication year - 2009
Publication title -
international journal for numerical methods in biomedical engineering
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.741
H-Index - 63
eISSN - 2040-7947
pISSN - 2040-7939
DOI - 10.1002/cnm.1274
Subject(s) - lattice boltzmann methods , platelet , immersed boundary method , mechanics , red blood cell , boundary value problem , blood flow , materials science , blood cell , chemistry , physics , biophysics , boundary (topology) , mathematics , biology , mathematical analysis , medicine , biochemistry , genetics , quantum mechanics , immunology
An Immersed Boundary method is developed in which the fluid's motion is calculated using the lattice Boltzmann method. The method is applied to explore the experimentally observed lateral redistribution of platelets and platelet‐sized particles in concentrated suspensions of red blood cells undergoing channel flow. Simulations capture red‐blood‐cell‐induced lateral platelet motion and the consequent development of a platelet concentration profile that includes an enhanced concentration within a few microns of the channel walls. In the simulations, the near‐wall‐enhanced concentration develops within approximately 400 ms starting from a random distribution of red blood cells and a uniform distribution of platelet‐sized particles. Copyright © 2009 John Wiley & Sons, Ltd.