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Overlap domain decomposition method for bioluminescence tomography (BLT)
Author(s) -
Wang Tao,
Gao Shuping,
Zhang Ling,
Wu Yan,
He Xiaowei,
Hou Yanbin,
Huang Heyu,
Tian Jie
Publication year - 2010
Publication title -
international journal for numerical methods in biomedical engineering
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.741
H-Index - 63
eISSN - 2040-7947
pISSN - 2040-7939
DOI - 10.1002/cnm.1242
Subject(s) - bioluminescence , domain decomposition methods , position (finance) , domain (mathematical analysis) , decomposition , algorithm , tomography , biological system , computer science , physics , finite element method , optics , mathematics , chemistry , biology , mathematical analysis , finance , economics , thermodynamics , biochemistry , organic chemistry
Bioluminescence tomography (BLT) allows in vivo localization and quantification of bioluminescent sources inside a small animal to reveal various molecular and cellular activities. In this paper, the overlap domain decomposition method (ODDM) of BLT is proposed, which refers to divide and conquer techniques for solving BLT by iteratively solving sub‐problems on smaller sub‐domains. Here, two triangulations of the region are adopted. We can obtain the photon density distribution on the object surface, as well as reconstruct the position of the light source by using ODDM and genetic algorithm. The numerical simulations have shown that ODDM is computationally efficient and fairly robust. Copyright © 2009 John Wiley & Sons, Ltd.