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Expression of multiple neuregulin transcripts in postnatal rat brains
Author(s) -
Chen Maio S.,
BerminghamMcDonogh Olivia,
Danehy Francis T.,
Nolan Colleen,
Scherer Steven S.,
Lucas Joy,
Gwynne David,
Marchionni Mark A.
Publication year - 1994
Publication title -
journal of comparative neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.855
H-Index - 209
eISSN - 1096-9861
pISSN - 0021-9967
DOI - 10.1002/cne.903490306
Subject(s) - biology , brainstem , neuroscience , cerebellum , diencephalon , forebrain , neuregulin , in situ hybridization , neuregulin 1 , hippocampus , basal forebrain , central nervous system , spinal cord , basal plate (neural tube) , gene expression , gene , receptor , genetics , pregnancy , fetus , placenta
The distribution of neuregulin transcripts in rat brains was studied by both RNA blotting and in situ hybridization. Our data demonstrate that multiple neuregulin transcripts are expressed in neurons of the basal forebrain, the hippocampus, the diencephalon, the cerebellum, the brainstem, and the spinal cord. Developmental changes in the distribution of neuregulin transcripts were observed only in the cerebellum and the hippocampus. The intense neuregulin hybridization signals in the brainstem motor and sensory nuclei and the spinal motor neurons are suggestive of a functional involvement of neuregulins in motor and sensory systems. The expression of neuregulins in other parts of the brain also indicates that these factors are involved in a variety of central nervous system functions. © 1994 Wiley‐Liss, Inc.