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Motor neurons in onuf's nucleus and its rat homologues express the p75 nerve growth factor receptor: Sexual dimorphism and regulation by axotomy
Author(s) -
Koliatsos Vassilis E.,
Price Donald L.,
Clatterbuck Richard E.
Publication year - 1994
Publication title -
journal of comparative neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.855
H-Index - 209
eISSN - 1096-9861
pISSN - 0021-9967
DOI - 10.1002/cne.903450404
Subject(s) - biology , axotomy , motor neuron , nucleus , bulbocavernosus reflex , neuroscience , neuron , neurotrophin , spinal cord , receptor , central nervous system , biochemistry
The present study establishes that populations of neurons in the lumbosacral cord, which innervate pelvic striated muscles, express p75 NGFR throughout their life spans. These neuronal groups comprise the Onuf's nucleus in humans and its principal rat homologues, dorsolateral (DL) and dorsomedial (DM) nuclei, as well as the cremasteric (CRE) nucleus. The p75 NGFR in these neurons is localized in the rough endoplasmic reticulum, Golgi complex, and lysosomes. Almost all neurons that project to striated perineal muscles in the male rat express p75 NGFR ; very low levels of p75 NGFR are detected in neurons that innervate perineal sphincters of the female. In the female rat, p75 NGFR expression is masculinized with perinatal androgen treatment. In addition, the expression of p75 NGFR in DM and DL neurons in the adult is up‐regulated by injury (i. e., pudendal axotomy) but is not influenced by gonadectomy. The results of this study establish that neurons of Onuf s nucleus and its rat homologues differ from general somatic motor neurons in that they express p75 NGFR from early postnatal life (i. e., when all motor neurons express p75 NGFR ) into the adult (when the former, but not the latter, express the receptor). In view of growing evidence for the role of neurotrophins in the physiology of motor neurons, the above differentiating feature between general somatic and sexually dimorphic motor neurons suggests that p75 NGFR may be involved in motor neuron plasticity and may participate in mechanisms by which neurons can protect themselves from degenerative insults. © 1994 Wiley‐Liss, Inc.