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Imparied motor axon regeneration in the C57BL/Ola mouse
Author(s) -
Chen S.,
Bisby M. A.
Publication year - 1993
Publication title -
journal of comparative neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.855
H-Index - 209
eISSN - 1096-9861
pISSN - 0021-9967
DOI - 10.1002/cne.903330310
Subject(s) - wallerian degeneration , sciatic nerve , axon , regeneration (biology) , crush injury , biology , neuroscience , anatomy , axotomy , sciatic nerve injury , medicine , microbiology and biotechnology , surgery
The delayed Wallerian degeneration which occurs in the C57BL/Ola mouse is associated with impaired motor axon regeneration. Following sciatic nerve crush, recovery of the sciatic functional index was delayed and incomplete when compared with recovery in C57BL/6J mice. After facial nerve crush, recovery of whisker movement in Ola mice was also delayed, and there was a prolonged period of partial recovery, not seen in 6J mice. Regeneration rate of the motor axons was measured by the axonal transport technique in sciatic nerve and was approximately 0.7 mm/d for Ola mice, and 4.0 mm/d for 6J mice. Combining these results from our previous work, we conclude that regeneration of both sensory and motor axons is imparired when Wallerian degeneration does not follow its usual time course after injury. © 1993 Wiley‐Liss, Inc.