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Cholinergic innervation of the human cerebellum
Author(s) -
de Lacalle Sonsoles,
Hersh Louis B.,
Saper Clifford B.
Publication year - 1993
Publication title -
journal of comparative neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.855
H-Index - 209
eISSN - 1096-9861
pISSN - 0021-9967
DOI - 10.1002/cne.903280304
Subject(s) - biology , choline acetyltransferase , cerebellum , granular layer , neuroscience , cholinergic , population , flocculus , cerebellar cortex , muscarinic acetylcholine receptor , mossy fiber (hippocampus) , purkinje cell , anatomy , microbiology and biotechnology , central nervous system , receptor , biochemistry , medicine , dentate gyrus , environmental health
Cholinergic innervation of the human cerebellum was investigated immunocytochemically by using a polyclonal rabbit antiserum against choline acetyltransferase. Immunoreactive structures were found throughout the cerebellar cortex but were localized predominantly in the vermis, flocculus, and tonsilla. These included (1) a population of Golgi cells in the granular layer; (2) a subpopulation of mossy fibers and glomerular rosettes; (3) thin, varicose fibers closely associated with the Purkinje cell layer and the molecular layer; and (4) a relatively dense network of fibers and terminals contributing to the glomerular formations in the granular layer. In the cerebellar nuclei, some cells stained positively for choline acetyltransferase, and a terminal field pattern could be detected with a distinct but sparse network of varicose fibers. Acetylcholine appears to be a primary transmitter in the vestibulocerebellar pathways at several levels, which may account for the potent effects of muscarinic antagonists in diminishing vestibular vertigo in humans. © 1993 Wiley‐Liss, Inc.