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Regional distribution of DARPP‐32 (Dopamine‐ 0M r = 32,000) mRNA in mouse brain
Author(s) -
Perez Ruth G.,
Lewis Robert M.
Publication year - 1992
Publication title -
journal of comparative neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.855
H-Index - 209
eISSN - 1096-9861
pISSN - 0021-9967
DOI - 10.1002/cne.903180307
Subject(s) - olfactory tubercle , piriform cortex , anterior olfactory nucleus , olfactory bulb , biology , stria terminalis , nucleus accumbens , entorhinal cortex , dopamine , hippocampus , neuroscience , medicine , anatomy , nucleus , central nervous system
DARPP‐32 (dopamine‐ and adenosine 3′,5′‐mbnophosphate‐regulated phosphoprotein of M r = 32,000) mRNA distribution was examined in adult mouse central nervous system by in situ hybridization. In general, DARPP‐32 mRNA was found in regions of brain where cells express the dopamine D 1 subtype receptor. Cells of the olfactory tubercle, caudate‐putamen, and nucleus accumbens had the highest levels of DARPP‐32 mRNA, as did choroid plexus and Purkinje cells. Relatively high levels were found in medial habenula and lateral piriform cortex. Moderate levels were seen in cerebral cortex layer VI, medial piriform cortex, lateral entorhinal cortex, tenia tecta, anterior olfactory nucleus, and lateral bed nucleus of the stria terminalis. Low levels were observed in hippocampus, cerebral cortex layers II and III, olfactory bulb, and the nucleus of the lateral olfactory tract. DARPP‐32 mRNA levels in the amygdaloid nuclei varied greatly.