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Ontogeny of gene expression of adenosine A2 receptor in the striatum: Early localization in the patch compartment
Author(s) -
Schiffmann S. N.,
Vanderhaeghen J.J.
Publication year - 1992
Publication title -
journal of comparative neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.855
H-Index - 209
eISSN - 1096-9861
pISSN - 0021-9967
DOI - 10.1002/cne.903170202
Subject(s) - biology , striatum , adenosine , in situ hybridization , receptor , adenosine receptor , dopamine , adenosine a1 receptor , medicine , ontogeny , endocrinology , dopamine receptor , neuron , dopamine receptor d1 , gene expression , neuroscience , gene , biochemistry , agonist
The ontogeny of adenosine A 2 receptor mRNA and adenosine A 2 , binding sites distributions was studied by in situ hybridization histochemistry and receptor autoradiography in pre‐ and post‐natal rat striatum, postnatal dog striatum, and a human fetus striatum and compared to that of dopamine D1 and μ opiate receptors. The early postnatal striatum demonstrated heterogeneous distributions of adenosine A 2 receptor mRNA and adenosine A 2 binding sites with patches of dense labeling corresponding to dopamine D1 and μ opiate receptors enriched zones. This patchy pattern evolved to the homogeneous distribution observed in the adult. The higher intensity of adenosine A 2 receptor mRNA enriched patches correspond at the microscopical level to a higher density of labeled neurons in the patches areas and also to a higher level expression per labeled patches neuron than in the matrix ones. This demonstrates for the first time that differences in patch/matrix receptor density is at least partly linked to different levels of receptor gene expression.