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Spatial relationships of axons arising from the substantia nigra, spinal trigeminal nucleus, and pedunculopontine tegmental nucleus within the intermediate gray of the cat superior colliculus
Author(s) -
Harting John K.,
Van Lieshout David P.
Publication year - 1991
Publication title -
journal of comparative neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.855
H-Index - 209
eISSN - 1096-9861
pISSN - 0021-9967
DOI - 10.1002/cne.903050403
Subject(s) - pedunculopontine tegmental nucleus , neuroscience , superior colliculus , biology , spinal trigeminal nucleus , anatomy , ventral tegmental area , midbrain , dorsal raphe nucleus , pedunculopontine nucleus , nucleus , tegmentum , substantia nigra , central nervous system , deep brain stimulation , dopamine , nociception , parkinson's disease , dopaminergic , medicine , biochemistry , receptor , disease , pathology , serotonergic , serotonin
We have utilized two different anterograde transport methods ( Phaseolus vulgaris leucoagglutinin [PHA‐L] immunocytochemistry and autoradiography) in the same experiment to compare the sublaminar location and arrangement of tectopetal axons arising from the substantia nigra pars reticulata, the spinal trigeminal nucleus, and the pedunculopontine tegmental nucleus. Our findings reveal that the nigrotectal projection terminates in a patchy fashion within three horizontally oriented sublaminae of the stratum griseum superficial (SGI), the dorsal, middle and ventral. The middle tier of nigrotectal axons exhibits an exquisite, puzzle‐like, complementary spatial relationship with trigeminotectal axons. In contrast, axons arising from the pedunculopontine tegmental nucleus overlap with patches of nigrotectal axons within the middle tier. Thus the middle tier of the SGI consists of domains of overlapping nigral and pedunculopontine tegmental inputs which interdigitate with domains rich in somatosensory inputs.