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Involvement of specific placental antigen X‐P 2 in rat olfaction: An immunohistochemical study in the olfactory bulb
Author(s) -
Shinoda Koh,
Yagi Hideo,
Osawa Yoshio,
Shiotani Yahe
Publication year - 1990
Publication title -
journal of comparative neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.855
H-Index - 209
eISSN - 1096-9861
pISSN - 0021-9967
DOI - 10.1002/cne.902940303
Subject(s) - olfactory bulb , biology , olfaction , olfactory system , immunohistochemistry , antigen , aromatase , receptor , olfactory receptor , medicine , endocrinology , neuroscience , central nervous system , immunology , biochemistry , cancer , breast cancer , genetics
Human placental antigen X‐P 2 (hPAX‐P 2 ), an antigen complex associated with cytochrome P‐450 of aromatase within estrogen synthesizing tissues, has been reported to be present in a distinct group of rat primary olfactory receptors involved in suckling behavior. In this study, most of the mitral and tufted cells in the rat olfactory bulb were found to possess hPAX‐P 2 immunoreactivity. This suggests that the activity of these cells can be hormonally modulated and that hPAX‐P 2 is involved in rat olfaction not only at the receptor level but also at integrative brain levels via the secondary projecting neurons of the olfactory pathway.