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Glutamic‐acid‐decarboxylase‐ and parvalbumin‐like‐immunoreactive structures in the olfactory bulb of the human adult
Author(s) -
Ohm T. G.,
Müller H.,
Ulfig N.,
Braak E.
Publication year - 1990
Publication title -
journal of comparative neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.855
H-Index - 209
eISSN - 1096-9861
pISSN - 0021-9967
DOI - 10.1002/cne.902910102
Subject(s) - olfactory bulb , granule cell , anterior olfactory nucleus , biology , immunolabeling , olfactory nerve , lipofuscin , axon , granule (geology) , microbiology and biotechnology , olfactory tubercle , granular layer , cell bodies , parvalbumin , anatomy , cerebellum , neuroscience , central nervous system , immunohistochemistry , biochemistry , immunology , paleontology , dentate gyrus
This study examines the distribution and morphological characteristics of glutamic‐acid‐decarboxylase‐like (GAD)‐ and parvalbumin‐like (PA)‐immunoreactive structures in the olfactory bulb of the human adult. GAD‐immunoreactive somata occurred in the glomerular layer, the external granule cell layer, the more superficial portion of the external plexiform layer, and the internal granule cell layer. The cells were small‐ to mediumsized. Demonstration of lipofuscin pigment revealed the presence of unpigmented as well as pigmented neurons, thus suggesting the existence of two subpopulations of GAD‐positive neurons. GAD‐immunoreactive puncta and/or fibers were mainly seen in the periglomerular region and the internal granule cell layer. All other layers of the bulb, as well as the intrabulbar portion of the anterior olfactory nucleus, displayed considerably less of these puncta and/or fibers. The olfactory nerve layer remained practically clear of immunoreactive material. PA‐immunoreactive somata occurred in the glomerular layer and both the external and internal granule cell layer. Only a small number of immunoreactive nerve cells were encountered within the white matter or the olfactory tract. Most PA‐positive neurons displayed characteristics of short axon cells whereas a few others resembled van Gehuchten cells. All of the PA‐immunoreactive neurons were devoid of lipofuscin pigment. Immunoreactive puncta and fibers were present in all layers though predominating in the periglomerular region, the olfactory nerve layer, and the internal granule cell layer. The intrabulbar portions of the anterior olfactory nucleus did not show any immunoreactive structures.