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Distribution of neuropeptide y‐containing perikarya and axons in various neocortical areas in the macaque monkey
Author(s) -
Kuljis Rodrigo O.,
Rakic Pasko
Publication year - 1989
Publication title -
journal of comparative neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.855
H-Index - 209
eISSN - 1096-9861
pISSN - 0021-9967
DOI - 10.1002/cne.902800305
Subject(s) - macaque , neuropeptide y receptor , neocortex , biology , neuroscience , neuropeptide , anatomy , laminar organization , sensory system , receptor , biochemistry
The laminar and areal distribution of neuropeptide Y (NPY)‐containing perikarya and their processes was analyzed immunocytochemically in Brodmann's neocortical areas 17, 18, 7, 22, 3, 4, 24, and 9 (Walker's area 46) in seven macaque monkeys. Most NPY‐containing cells are distributed in two broad bands in layers II–III and V–VI in all areas; relatively few cells can be found in layer I and virtually none in layer IV. Numerous NPY‐containing cells are situated in the white matter immediately subjacent to the cortical gray. Severalfold regional and individual differences in the density of NPY‐positive somata were found in supra‐ and infragranular layers. However, the interareal variations in the density of NPY‐containing somata do not conform to a universal pattern, because of either individual variability or inherent difficulties in standardizing immunocytochemical labeling. In contrast, the laminar differences in the distribution of NPY‐containing axons among cortical areas are consistent in all animals. In general, primary sensory and motor areas have a lesser density of NPY‐containing axons than association and limbic areas. Within this general pattern, area‐specific laminar segregation of NPY‐containing axons occurs. The regional differences in the distribution of NPY‐like immunoreactivity in the neocortex may reflect innate characteristics of local neuronal circuits serving specialized functions.