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Neuroanatomical distribution of receptors for three potential inhibitory neurotransmitters in the brainstem auditory nuclei of the cat
Author(s) -
Glendenning Karen K.,
Baker Barbara N.
Publication year - 1988
Publication title -
journal of comparative neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.855
H-Index - 209
eISSN - 1096-9861
pISSN - 0021-9967
DOI - 10.1002/cne.902750210
Subject(s) - lateral lemniscus , inferior colliculus , muscimol , biology , neuroscience , glycine receptor , muscarinic acetylcholine receptor , strychnine , brainstem , inhibitory postsynaptic potential , superior olivary complex , nucleus , receptor , gabaa receptor , glycine , biochemistry , amino acid
In order to visualize the relative abundance of each of three potentially inhibitory neurotransmitters in the nuclei of the brainstem auditory pathway, receptor sites for glycine, GABA‐A, and muscarinic acetylcholine (ACh) have been localized in the cat's brainstem auditory system. Conventional autoradiographic receptor‐binding procedures were used and the distributions of the receptors were inferred from the respective distributions of tritiated strychnine, muscimol, and quinuclidinyl benzilate (QNB) binding sites. The results show that glycine may be the major inhibitory neurotransmitter in the auditory system as it ascends to the midbrain in that relatively high levels of strychnine binding are present in every major nucleus of the system. In contrast, high levels of muscimol binding of high‐affinity GABA‐A receptors are confined mostly to the dorsal cochlear nucleus, the dorsal nucleus of the lateral lemniscus, and the central and cortical regions of the inferior colliculus, while high levels of QNB binding of muscarinic ACh receptors are seen only in the central and cortical regions of the inferior colliculus.