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Development of β 1 and β 2 adrenergic receptors in baboon brain: An autoradiographic study using [ 125 I]iodocyanopindolol
Author(s) -
Slesinger Paul A.,
Lowenstein Pedro R.,
Singer Harvey S.,
Walker Lary C.,
Casanova Manuel F.,
Price Donald L.,
Coyle Joseph T.
Publication year - 1988
Publication title -
journal of comparative neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.855
H-Index - 209
eISSN - 1096-9861
pISSN - 0021-9967
DOI - 10.1002/cne.902730304
Subject(s) - globus pallidus , biology , putamen , striatum , receptor , forebrain , baboon , caudate nucleus , hippocampus , neuroscience , cerebral cortex , iodocyanopindolol , medicine , endocrinology , basal ganglia , dopamine , central nervous system , agonist , biochemistry , intrinsic activity
[ 125 I]iodocyanopindolol (ICYP) autoradiography was used to investigate the temporal development and distribution of β 1 and beta; 2 receptors in brains of baboons at ages embryonic day 100 (E100), full‐term gestation (E180), and 3 years. In all brain regions examined, with the exception of the hippocampus, binding to β 1 receptors exceeded that to β 2 receptors. The highest densities of ββ 1 receptors were found in the caudate nucleus, putamen, globus pallidus, substantia nigra, and cerebral cortex; intermediate receptor densities were observed in most nuclei of thalamus, and the lowest concentrations were in the hippocampus. At E100, β 1 receptors were identified in the striatum, globus pallidus, and thalamus. During maturation, the number of β 1 receptors declined in cortical areas but increased in the head of the caudate and putamen. Significant differences in the developmental distribution of β 1 receptors during development were also detected: at E100 and E180 β 1 receptors appeared as patches in the caudate and putamen, but by 3 years of age they were more homogeneously distributed in both regions; changes also occurred in the distribution of binding within cortical layers. Autoradiograms of [ 125 I]ICYP and [ 3 H]mazindol binding show overlapping patches of labeling in the E180 striatum, suggesting a possible developmental association between β receptors and dopamine high‐affinity uptake carrier sites. This study demonstrates that noradrenergic receptors in the primate forebrain undergo significant developmental reorganization with regional variations.