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FMRFamide‐ and adipokinetic hormone‐like immunoreactivity in the nervous system of the mosquito, Aedes aegypti
Author(s) -
Brown Mark R.,
Lea Arden O.
Publication year - 1988
Publication title -
journal of comparative neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.855
H-Index - 209
eISSN - 1096-9861
pISSN - 0021-9967
DOI - 10.1002/cne.902700413
Subject(s) - fmrfamide , biology , antiserum , aedes aegypti , immunocytochemistry , midgut , neuropeptide , medicine , pancreatic polypeptide , nervous system , adipokinetic hormone , endocrinology , hormone , antigen , biochemistry , immunology , neuroscience , larva , glucagon , botany , receptor
As demonstrated with immunocytochemistry, specific cells and axons in the nervous system of female Aedes aegypti contain antigens immunologically related to FMRFamide (phenylalanine‐methioninevarginine‐phenylalaninevamide) and locust adipokinetic hormone I (AKH). In the supravesophageal ganglion, including some medial neurosecretory cells, and in all ganglia of the ventral nerve cord, there are 100–120 cells immunoreactive to a FMRFamide antiserum. The same cells cross‐react with a bovine pancreatic polypeptide antiserum, but when the latter antiserum is preabsorbed with FMRFamide, immunoreactivity is lost. However, immunoreactivity is maintained when FMRFamide antiserum is preabsorbed with pancreatic polypeptide, suggesting that the immunoreactive peptide is more closely related to FMRFamide. There are 6–12 cells in the supra‐ and subesophageal ganglia immunoreactive to an AKH antiserum, and some of the same cells are reactive to the FMRFamide antiserum. As well, unpaired cells in each of the abdominal ganglia are positive for both AKH and FMRFamide. Although the function of the FMRFamidev and AKH‐like peptides in mosquitoes is unknown, this study, combined with previous reports on the localization of FMRFamidevlike peptides in midgut endocrine cells, supports the concept of a brain‐midgut neuroendocrine axis in this insect.

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