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Somatostatin‐like immunoreactivity in the midbrain of the cat
Author(s) -
Spangler Kevin M.,
Morley Barbara J.
Publication year - 1987
Publication title -
journal of comparative neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.855
H-Index - 209
eISSN - 1096-9861
pISSN - 0021-9967
DOI - 10.1002/cne.902600108
Subject(s) - interpeduncular nucleus , midbrain , superior colliculus , tegmentum , biology , inferior colliculus , periaqueductal gray , parabrachial nucleus , midbrain reticular formation , anatomy , neuroscience , nucleus , substantia nigra , pretectal area , dorsal raphe nucleus , central nervous system , dopamine , dopaminergic , serotonergic , serotonin , biochemistry , receptor
Somatostatin (SS) immunoreactivity was localized in cat brain sections with an immunoperoxidase technique. Cell bodies in the midbrain containing SS immunoreactivity were found in the superficial and intermediate gray layers of the superior colliculus, the interpeduncular nucleus, the raphe, the inferior colliculus and nucleus of its brachium, the nucleus of the optic tract, and the lateral tegmental field. Additional positive neurons were seen in the parabigeminal nucleus and in the dorsal periaqueductal gray in kitten material. Immunoreactive fibers were observed in the periaqueductal gray and in the midbrain tegmentum, with particularly dense labeling just dorsal to the substantia nigra and in the parabrachial nuclei. This is the first report of the distribution of SS immunoreactivity in the midbrain of the cat. It is concluded that somatostatin has a distribution compatible with a role as a major neurotransmitter/neuromodulator within oertain midbrain nuclei, especially the interpeduncular nucleus and the superior colliculus.