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A horseradish peroxidase study of the rubral and cortical afferents to the lateral reticular nucleus in the rat
Author(s) -
Shokunbi M. T.,
Hrycyshyn A. W.,
Flumerfelt B. A.
Publication year - 1986
Publication title -
journal of comparative neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.855
H-Index - 209
eISSN - 1096-9861
pISSN - 0021-9967
DOI - 10.1002/cne.902480312
Subject(s) - biology , red nucleus , neuroscience , horseradish peroxidase , anatomy , cerebellum , lateral reticular nucleus , reticular formation , brainstem , cerebral cortex , nucleus , thalamic reticular nucleus , thalamus , axoplasmic transport , cortex (anatomy) , cuneate nucleus , cerebrum , reticular connective tissue , central nervous system , medulla oblongata , biochemistry , enzyme
The origin and organization of supraspinal afferents to the lateral reticular nucleus (LRN) in the rat were studied by means of the retrograde axonal transport of horseradish peroxidase (HRP). HRP was deposited into the LRN via both dorsal (stereotaxic) and ventral (microsurgical) routes. The entire cerebrum, brainstem, and cerebellum were surveyed for retrogradely labelled neurons. Significant projections arose from the contralateral red nucleus and the contralateral frontoparietal cortex. The rubral projection arose from neurons in the caudal two‐thirds of the red nucleus. Ventrally and ventrolaterally located neurons projected to rostrolateral LRN, while dorsal and dorsomedial neurons projected to rostromedial LRN. The projection from the cerebral cortex arose from neurons located in layer V of the frontoparietal region. Rubral and cerebrocortical projections overlap in the rostral LRN, making this region of the nucleus a site of integration of descending inputs with ascending spinal signals.