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Experimental immunohistochemical studies on the substance P neuron system in the lateral habenular nucleus of the rat: Distribution and origins
Author(s) -
Shinoda Koh,
Inagaki Shinobu,
Shiosaka Sadao,
Kohno Jōji,
Tohyama Masaya
Publication year - 1984
Publication title -
journal of comparative neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.855
H-Index - 209
eISSN - 1096-9861
pISSN - 0021-9967
DOI - 10.1002/cne.902220409
Subject(s) - nucleus , biology , anatomy , habenula , substance p , distribution (mathematics) , immunohistochemistry , neuroscience , central nervous system , neuropeptide , receptor , mathematical analysis , biochemistry , mathematics , immunology
We examined the distribution and afferent projections of substance P‐like immunoreactive (SPI) fibers in the lateral habenular nucleus of the rats by using the indirect immunofluorescence method. On the basis of the distribution, a dense plexus of SPI fibers in the lateral habenular nucleus (LHb) could be divided into two parts: medial (mLHb) and lateral (lLHb). The present study demonstrates that SPI fibers in the lLHb originate from SPI cells in the rostral entopeduncular nucleus (rEP) and the adjacent area, while those in the mLHb originate from SPI cells in the medial habenular nucleus. Moreover, we showed that the axons from SPI cells in the rEP reached the lLHB via the “pallidohabenular tract.”