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The contribution of late‐generated neurons to the callosal projection in the rat: A study with prenatal x‐irradiation
Author(s) -
Jensen Karl F.,
Altman Joseph
Publication year - 1982
Publication title -
journal of comparative neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.855
H-Index - 209
eISSN - 1096-9861
pISSN - 0021-9967
DOI - 10.1002/cne.902090202
Subject(s) - corpus callosum , neocortex , biology , neuroscience , horseradish peroxidase , projection (relational algebra) , anatomy , population , computer science , biochemistry , demography , algorithm , sociology , enzyme
Studies utilizing horseradish peroxidase tracing methods have suggested that there are species differences in the relative contribution of the different neocortical layers to the callosal projection. The present investigation utilized x‐irradiation at different gestational ages to eliminate the late‐generated neurons of the rat neocortex. The caudorostral gradient of reduction in the neuronal population of the supragranular layers is closely correlated with the gradient of reduction in the size of the corpus callosum. Furthermore, the callosal projection is absent in anteroposterior cortical segments in which the development of the supragranular layers was prevented without a reduction of the number of neurons in the infragranular layers of the neocortex. These results indicate that late‐generated neurons residing primarily in the supragranular layers are essential for the formation of the corpus callosum.