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Ontogeny of the leucine‐enkephalin neuron system of the rat: Immunohistochemical analysis. I. Lower brainstem
Author(s) -
Senba Emiko,
Shiosaka Sadao,
Hara Yoshinobu,
Inagaki Shinobu,
Kawai Yuriko,
Takatsuki Kenichi,
Sakanaka Masahiro,
Iida Hisashi,
Takagi Hiroshi,
Minagawa Hideo,
Tohyama Masaya
Publication year - 1982
Publication title -
journal of comparative neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.855
H-Index - 209
eISSN - 1096-9861
pISSN - 0021-9967
DOI - 10.1002/cne.902050404
Subject(s) - brainstem , biology , reticular formation , ontogeny , anatomy , reticular connective tissue , fetus , medulla oblongata , neuron , central nervous system , neuroscience , endocrinology , pregnancy , genetics
Ontogeny of the leucine‐enkephalin (L‐Enk) neuron system in the lower brainstem of the rat was investigated by means of indirect immunofluorescence. L‐Enk‐containing cells first appear in the primordium of the medullary reticular formation just medial to the n. tractus spinalis nervi trigemini at the level of the rostral half of the inferior olivary nucleus, in the n. cuneiformis, and in the mesencephalic reticular formation of the fetus at gestational day 16 (14–15‐mm embryos). From that time onward, L‐Enk‐containing cells appear in various areas of the lower brainstem one after another until birth. After birth, although L‐Enk‐containing cells decrease slightly in number as the rats grow, L‐Enk‐containing fibers continue to increase in number.