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Anatomical demonstration of multiple representation in the forelimb region of the cat motor cortex
Author(s) -
Pappas C. L.,
Strick P. L.
Publication year - 1981
Publication title -
journal of comparative neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.855
H-Index - 209
eISSN - 1096-9861
pISSN - 0021-9967
DOI - 10.1002/cne.902000404
Subject(s) - forelimb , neuroscience , anatomy , corpus callosum , motor cortex , biology , cortex (anatomy) , representation (politics) , stimulation , politics , political science , law
Retrograde transport of HRP was employed to examine the pattern of callosal connections in the forelimb region of area 4$ in the cat. According to the conventional view, areas of the motor cortex which contain the representation of distal body parts neither send nor receive callosal fibers. If this is true, then an absence of callosal connections would define the sites of distal forelimb representation. Following multiple injections of HRP into the contralateral motor cortex, many labeled neurons were found in the forelimb region of area 4$. However, within this region, two spatially separate areas were found where labeled neurons were either absent or present in very low density (“callosal holes”). The anatomically defined callosal holes corresponded in size, shape, and location to the physiologically defined digit zones. To provide direct evidence for this correspondence, retrograde HRP transport was combined with intracortical stimulation in the same animal. Small lesions placed in physiologically identified digit zones were located within the anatomically defined callosal holes. Thus, a double representation of the distal forelimb can be defined in area 4γ of the cat motor cortex using both anatomical and physiological methods.