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Single subthalamic nucleus neurons project to both the globus pallidus and substantia nigra in rat
Author(s) -
Van Der Kooy Derek,
Hattori T.
Publication year - 1980
Publication title -
journal of comparative neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.855
H-Index - 209
eISSN - 1096-9861
pISSN - 0021-9967
DOI - 10.1002/cne.901920409
Subject(s) - subthalamic nucleus , globus pallidus , substantia nigra , medium spiny neuron , biology , 5 ht4 receptor , basal ganglia , neuroscience , red nucleus , axon , zona incerta , retrograde tracing , axoplasmic transport , pars reticulata , anatomy , nucleus , deep brain stimulation , central nervous system , parkinson's disease , dopamine , pathology , medicine , dopaminergic , biochemistry , receptor , disease , serotonin
Abstract The organization of the major efferents of the rat subthalamic nucleus (STN) was investigated using a fluorescent retrograde double‐labeling technique. Red fluorcrescent Evans Blue was injected into the globus pallidus and blue fluorescent DAPI‐Primuline was injected into the substantia nigra. After retrograde axonal transport many double‐labeled neurons were seen throughout the STN. Occasional double‐labeled cells were seen in the lateral hypothalamus just medial to the STN and in a thin lateral strip of neurons extending laterally from the STN. Evidence for a mediolateral topography in both the STN‐pallidal and STN‐nigral pathways was obtained. The STN contains few, if any, local interneurons. Cell counts revealed that at least 94% of, and possibly all, STN neurons send axon collaterals to both the globus pallidus and substantia nigra.