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Neurons in cat lateral geniculate nucleus that concentrate exogenous [ 3 H]‐γ‐aminobutyric acid (GABA)
Author(s) -
Sterling Peter,
Davis Thomas L.
Publication year - 1980
Publication title -
journal of comparative neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.855
H-Index - 209
eISSN - 1096-9861
pISSN - 0021-9967
DOI - 10.1002/cne.901920408
Subject(s) - muscimol , biology , geniculate , aminobutyric acid , neuroscience , lateral geniculate nucleus , gamma aminobutyric acid , golgi apparatus , retinal , biophysics , nucleus , visual cortex , agonist , biochemistry , cell , receptor
About one‐quarter of the neurons in the A‐laminae of the cat lateral geniculate selectively accumulate exogenous [ 3 H]‐γ‐aminobutyric acid (GABA), its analog, [ 3 H]‐2,4‐diaminobutyric acid (DABA), and the GABA agonist, [ 3 H] muscimol. These neurons are small (12–18 μm diameter) and lack a laminar body, which suggests that they correspond to the class III cell identified in Golgi material. GABA and DABA are also accumulated by F‐terminals which are post‐synaptic to retinal terminals and presynaptic to relay cell dendrites. It is suggested that GABA may be the transmitter for these small neurons which appear to mediate by means of local circuits a feed‐forward inhibition onto the relay cells.