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The islands of calleja: Organization and connections
Author(s) -
Fallon James H.,
Riley Joseph N.,
Sipe Jack C.,
Moore Robert Y.
Publication year - 1978
Publication title -
journal of comparative neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.855
H-Index - 209
eISSN - 1096-9861
pISSN - 0021-9967
DOI - 10.1002/cne.901810209
Subject(s) - olfactory tubercle , biology , nucleus accumbens , basal forebrain , neuroscience , retrograde tracing , anterograde tracing , anterior olfactory nucleus , anatomy , ventral tegmental area , population , cytoarchitecture , ventral pallidum , midbrain , piriform cortex , axoplasmic transport , horseradish peroxidase , nucleus , basal ganglia , dopamine , globus pallidus , amygdala , central nervous system , dopaminergic , demography , sociology , biochemistry , enzyme
The islands of Calleja (IC) in the rat are composed of seven small groups of granule cells in the polymorph layer of the olfactory tubercle and one large group, the insula magna, which lies along the border between septum, nucleus accumbens and nucleus of the diagonal band. The cytoarchitecture and neuronal morphology of the IC and surrounding cells, studied using Nisslstained and Golgi‐Kopsch material, are described. In addition, the afferent and efferent connections of the IC were analyzed using fluorescence histochemistry, the autoradiographic tracing method, and the anterograde and retrograde horseradish peroxidase methods. Topographically organized projections to the IC from the dopamine‐containing cells of the substantia nigra‐ventral tegmental area are demonstrated by the glyoxylic acid fluorescence histochemical method and the autoradiographic tracing technique. Anterograde and retrograde horseradish peroxidase studies provide evidence for reciprocal, topographically organized interconnections between the IC and the septum, nucleus accumbens, amygdala and piriform cortex. These observations indicate that the IC constitute a unique population of granule cells, located in the olfactory tubercle, innervated by dopamine neurons of the mesencephalon and interconnected with olfactory and non‐olfactory components of the basal forebrain.