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Histology and ultrastructure of the carotid sinus in experimental hypertension
Author(s) -
Rees Peter M.,
Sleight Peter,
Robinson James L.,
Bonchek Lawrence I.,
Doctor Aspi
Publication year - 1978
Publication title -
journal of comparative neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.855
H-Index - 209
eISSN - 1096-9861
pISSN - 0021-9967
DOI - 10.1002/cne.901810203
Subject(s) - baroreceptor , lumen (anatomy) , calcification , carotid sinus , biology , histology , blood pressure , ultrastructure , sinus (botany) , anatomy , pathology , medicine , endocrinology , heart rate , botany , genus
Histological studies including electron microscopy were performed on the carotid sinuses of dogs with renal hypertension of 17 to 82 days duration or hypertension of two years secondary to aortic coarctation. Physiological abnormalities in the baroreceptors including resetting had been demonstrated before death. Histologically there were no qualitative or quantitative differences in the intrasinus nerve fibers of the hypertensive animals compared to controls with normal blood pressures, and there was no evidence that baroreceptor degeneration occurred as a consequence of the hypertension. Structural lesions confined to the intima were evident in the sinus walls of some of the renal hypertensive animals whereas the dogs with coarctation showed more advanced sinus wall changes including medial calcification and enlargement of the vascular lumen.