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Abnormalities of the cortico‐geniculate pathway in siamese cats
Author(s) -
Montero V. M.,
Guillery R. W.
Publication year - 1978
Publication title -
journal of comparative neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.855
H-Index - 209
eISSN - 1096-9861
pISSN - 0021-9967
DOI - 10.1002/cne.901790102
Subject(s) - cats , geniculate , enucleation , lamina , lateral geniculate nucleus , anatomy , biology , geniculate ganglion , neuroscience , retina , pathology , medicine , nucleus , genetics , alternative medicine , palsy
The cortico‐geniculate pathways of normally‐pigmented and Siamese cats have been studied by autoradiography following injections of 3 H proline into cortical area 17. Normal Siamese cats and Siamese cats that were raised with one eye sutured or removed have been compared with normally‐pigmented cats treated in the same manner. The cortico‐geniculate projection from area 17 passes to all parts of the lateral geniculate nucleus in normal cats and distributes to all geniculate layers (Updyke, '76). This distribution was essentially unaffected by an early monocular suture or enucleation. In Siamese cats, the cortico‐geniculate projection to lamina A and to the lateral normal segment of lamina A1 was normal, but little or no label was seen in the abnormal segment of lamina A1. The interlaminar zones adjacent to the abnormal segment of lamina A1 were densely filled with label, as though the cortico‐geniculate axons avoid this segment. Unilateral enucleation or lid‐suture did not affect this distribution, suggesting that it does not depend upon visual experience. These Siamese cats were all identified by electrophysiological studies as having a normal topography of the geniculo‐cortical pathways. That is, they were “Midwestern” cats.