Premium
The distribution of substance P immunoreactive fibers in the rat central nervous system
Author(s) -
Cuello A. Claudio,
Kanazawa Ichiro
Publication year - 1978
Publication title -
journal of comparative neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.855
H-Index - 209
eISSN - 1096-9861
pISSN - 0021-9967
DOI - 10.1002/cne.901780108
Subject(s) - substance p , central nervous system , biology , globus pallidus , neuroscience , thalamus , nucleus , sensory system , neocortex , nervous system , anatomy , basal ganglia , neuropeptide , receptor , biochemistry
A detailed account of the distribution of immunoreactive substance P‐containing structures in the rat central nervous system is presented, from results obtained by applying an indirect immunofluorescent technique. High densities of substance P‐containing nerve terminals were present in sensory nuclei and other non‐sensory structures such as thalamus, hypothalamus and extrapyramidal system. Substance P‐reactive neuron cell bodies were present in spinal root ganglia, nucleus habenulae medialis, nucleus interpeduncularis, caudoputamen and globus pallidus. Most of the neocortex and the cerebellar cortices had no substance P‐positive elements. The results support the hypothesis that substance P may be a widespread neurotransmitter in the central nervous system.