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Cerebellar histogenesis in the lurcher ( Lc ) mutant mouse
Author(s) -
Swisher Dorothy A.,
Wilson Doris B.
Publication year - 1977
Publication title -
journal of comparative neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.855
H-Index - 209
eISSN - 1096-9861
pISSN - 0021-9967
DOI - 10.1002/cne.901730112
Subject(s) - cerebellar cortex , cerebellum , biology , granule cell , purkinje cell , granule (geology) , granular cell , programmed cell death , histogenesis , granular layer , neuroscience , anatomy , cytoplasm , microbiology and biotechnology , immunology , central nervous system , apoptosis , genetics , dentate gyrus , paleontology , immunohistochemistry
The postnatal development of the cerebellar cortex of normal and lurcher ( Lc ) mutant mice was studied by neurohistological and autoradiographic techniques at ages ranging from 2 days through 18 days after birth. Lurcher shows severe defects in the granule cells and Purkinje cells soon after birth. A decrease in the generative layers of the external granular layer is soon as early as two days in the lobulus simplex and by six days of age in the uvula. Granule cell death is common before and during granule cell migration, from 2 to 18 days of age. Loss of granule cells is reflected in reduced growth of the molecular and granular layers. Purkinje cell abnormalities appear at three to four days after birth in the form of crowding, failure of nuclear growth, and condensed or lessened cytoplasm. Purkinje cell death is apparent at four to six days of age depending on the region of the cerebellum.