The olivocerebellar projection in the cat studied with the method of retrograde axonal transport of horseradish peroxidase. IV. The projection to the anterior lobe

Abstract Following injections of horseradish peroxidase (HRP) in the cerebellar cortex of the anterior lobe of the cat, the distribution of labeled cells in the inferior olive was mapped. The findings largely confirm those made previously in studies of olivary retrograde cell loss following cerebellar ablations (Brodal, 1940b). In addition, they reveal further olivary areas projecting onto the anterior lobe, and permit a more detailed analysis of the pattern in this projection. Concerning major points the results are in agreement with physiological studies by Armstrong et al. (1974). They bring supporting evidence for a longitudinal zonal pattern in the anterior lobe (fig. 6C). The middle zone of the vermis receives its fibers from a large central area in the caudal half of the medial accessory olive, a lateral zone of the vermis from the lateral half of the dorsal accessory olive. Both olivary areas project to the corresponding cerebellar zone throughout lobules V‐I. The lateralmost part of the anterior lobe (lobules IV‐V) receives afferents from an area in the dorsal lamella of the principal olive. The intermediate part of lobules IV‐V receives afferents from the medial half of the dorsal accessory olive and from an area in the rostral half of the medial accessory olive. There is suggestive evidence that the latter projects lo a middle zone, the former to a medial and a lateral zone within the intermediate part as found physiologically. Conclusions concerning projections to the intermediate part of lobules III‐II could not be made. The findings in this and preceding studies with the HRP‐method show that the concept of a longitudinal pattern in the cerebellum is scarcely generally valid of the entire olivocerebellar projection. Within the projections of the lateral half of the dorsal accessory olive and the area in the rostral part of the medial accessory olive there appears to be a topical relation with the folial pattern in the anterior lobe. An analysis of the findings with reference to the afferents traced anatomically to the various olivary areas permits some conclusions as to the functional role of the olivary areas. Comparison with Oscarsson's (1973) diagram of the sites of termination of two of the spinal‐olivary pathways (his DF‐SOCP and VF‐SOCP) permits an anatomical explanation as concerns the projections to the vermis, while correlations as concerns the intermediate part are less satisfactory.