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Olfactory structures of the forebrain in the reeler mutant mouse
Author(s) -
Caviness V. S.,
Sidman R. L.
Publication year - 1972
Publication title -
journal of comparative neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.855
H-Index - 209
eISSN - 1096-9861
pISSN - 0021-9967
DOI - 10.1002/cne.901450106
Subject(s) - reeler , olfactory bulb , olfactory tubercle , biology , cytoarchitecture , anterior olfactory nucleus , neuroscience , piriform cortex , neocortex , cresyl violet , forebrain , olfactory system , anatomy , biotinylated dextran amine , cerebral cortex , subiculum , hippocampus , nucleus , central nervous system , mutant , dentate gyrus , genetics , staining , gene
Prior studies in the reeler mutant mouse have drawn attention to cytoarchitectonic anomalies in the neocortex and hippocampus of the forebrain and in the cerebellar cortex. In the present study cresyl violet and Loyez stained serial sections were used for light microscopic analysis of the olfactory structures in the forebrain of the mutant. The olfactory bulb and accessory bulb, both targets of afferents form the peripheral nervous system, are normal. By contrast, the laminate structures to which the olfactory bulbs project — the anterior olfactory nucleus, piriform cortex, olfactory tubercle, and cortical nucleus of the amygdaloid complex — are all abnormal in their cytoarchitecture. All of these structures share in common a segregation of cell populations according to size such that the larger cells lie in a deep position close to central fiber bundles. Small, polymorphic cells occupy a superficial zone, and there is no cellsparse external plexiform layer in the mutant. We adopt the view that the relationship of pyramidal cell to complex, external plexiform layer is the cardinal geometric principle defining a normal cortex, and suggest that derangement of this relationship may be the common denominator in the reeler cortical phenotype. The developmental mechanism influenced by the reeler locus and leading to the fundamental cortical geometry in normal or mutant animals may reside in the early interaction of afferent fibers and pyramidal cells.