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Peripheral synaptogenesis in nerve parabiosis
Author(s) -
Estable Clemente,
Reissenweber Nelson J.,
Benedetti Washington L.
Publication year - 1969
Publication title -
journal of comparative neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.855
H-Index - 209
eISSN - 1096-9861
pISSN - 0021-9967
DOI - 10.1002/cne.901360103
Subject(s) - biology , parabiosis , synaptogenesis , sciatic nerve , anatomy , motor nerve , stimulation , regeneration (biology) , stimulus (psychology) , electrophysiology , neuromuscular junction , peripheral , neuroscience , gastrocnemius muscle , peripheral nerve , motor neuron , medicine , endocrinology , microbiology and biotechnology , skeletal muscle , spinal cord , psychology , psychotherapist
One hundred and ninety‐two rats were parabiotically coupled to test regeneration of the sciatic nerve of the “donor” rat in the denervated gastrocnemius of the “host.”. Proliferation of the implanted nerve was clearly demonstrated after 30 days. Histological and histochemical study revealed the formation of motor end‐plates of increasing complexity and after survival of 300 days mature motor end‐plates were observed. The electrophysiological study demonstrated that the muscle responded to stimulation of the nerve with normal stimulus. The immunological interaction did not interfere with the formation of “functional” motor end‐plates and central nerve centers of the “donor” rat are capable of eliciting motor activity of the limb of the “host.”.