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Cerebellar cortex of rat and other animals . A structural and ultrastructural study
Author(s) -
O'Leary James L.,
Petty Jerry,
Smith Jeanne M.,
O'Leary Mary,
Inukai Joseph
Publication year - 1968
Publication title -
journal of comparative neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.855
H-Index - 209
eISSN - 1096-9861
pISSN - 0021-9967
DOI - 10.1002/cne.901340404
Subject(s) - golgi apparatus , ultrastructure , biology , axon , cerebellar cortex , anatomy , degeneration (medical) , neuroscience , cerebellum , pathology , endoplasmic reticulum , microbiology and biotechnology , medicine
Cerebellar cortex was studied in 100 rats and other animals, 15–30 days old, using Golgi, intravitam methylene blue, and ultrastructural methods. Marchi and Nauta provided certain controls. Degeneration of afferent terminals was sought following lesions of pons and olive. In normal material, emphasis was upon the changing field relations between folial summit, side wall, and sulcus, Many previous findings of Fox, Ramon y Cajal and Snider were confirmed, and the effort made to reconcile departures from characteristic axonal and dendritic configuration with cytoarchitectonic pattern. Mossy and climbing terminals were examined in normal and degenerated states, using Golgi and ultrastructural material. Climbing fibers in Golgi are described in detail, including variations in course and sites of branchings. Mossy degeneration was found 3–5 days after lesions of both pons and olive. The clearest evidence thereof was provided in ultrastructural material. Minor evidences of degeneration were also found in climbing fiber strands in both materials, but on gross degeneration was encountered. Corresponding Golgi material was used for visualizing intact fibers in the face of adequate lesions. Ultrastructure also provided evidence concerning the axon cap surround, the initial segment of the Purkinje axon, Comparison with these segmests in other cell types, and cross‐identification of synapses between axon types and the different cell profiles of Golgi material.