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Correlation of glial proliferation with age in the mouse brain
Author(s) -
Dalton Mary Margaret,
Hommes O. R.,
Leblond C. P.
Publication year - 1968
Publication title -
journal of comparative neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.855
H-Index - 209
eISSN - 1096-9861
pISSN - 0021-9967
DOI - 10.1002/cne.901340403
Subject(s) - corpus callosum , biology , striatum , thymidine , neuroscience , neuroglia , correlation , central nervous system , endocrinology , genetics , in vitro , dopamine , geometry , mathematics
Radioautographs of brain sections were prepared after injection of 3 H‐thymidine into mice aged 23, 100, 200 or 400 days. The presence of a small number of labeled cells in all animals indicates that neuroglia do proliferate even at an advanced age. Proliferation is most active in the corpus callosum and least so in the corpus striatum. Comparison of the counts of labeled and unlabeled nuclei suggests that glial cells are produced in numbers exceeding growth requirements and, accordingly, that they turn over, although slowly.