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Numerical estimates of neurons and glia in lateral geniculate body during retrograde degeneration
Author(s) -
Chow Kao Liang,
Dewson James H.
Publication year - 1966
Publication title -
journal of comparative neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.855
H-Index - 209
eISSN - 1096-9861
pISSN - 0021-9967
DOI - 10.1002/cne.901280106
Subject(s) - biology , degeneration (medical) , geniculate body , cats , neuroglia , microglia , geniculate , anatomy , neuroscience , lateral geniculate nucleus , astrocyte , cortex (anatomy) , nucleus , visual cortex , pathology , central nervous system , medicine , immunology , inflammation
Studies were made of decrease of neurons and proliferation of glial cells in the dorsal nuclei of lateral geniculate body of 32 rabbits and 12 cats who had undergone unilateral ablation of visual cortex up to 50 weeks prior to sacrifice. Results show that degeneration occurred in 80% of neurons in rabbit lateral geniculate body within three days, and 95% disappeared within four weeks. In comparison, degeneration was present in only 70% of neurons in the cat nucleus at the seventh post‐operative day, and about 26% remained normal up to the fiftieth week. Glial cell reactions were differential and complex: astrocytes showed rapid proliferation with gradual return to normal, while oligodendrocytes and microglia increased more slowly, maintaining a high level over 50 weeks.