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Projections from the dorsomedial division of the bed nucleus of the stria terminalis to hypothalamic nuclei in the mouse
Author(s) -
Barbier Marie,
González J. Antonio,
Houdayer Christophe,
Burdakov Denis,
Risold PierreYves,
Croizier Sophie
Publication year - 2021
Publication title -
journal of comparative neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.855
H-Index - 209
eISSN - 1096-9861
pISSN - 0021-9967
DOI - 10.1002/cne.24988
Subject(s) - stria terminalis , biology , amygdala , septal nuclei , neuroscience , nucleus , hypothalamus , retrograde tracing , arcuate nucleus , central nucleus of the amygdala , extended amygdala , ventral pallidum , proopiomelanocortin , periventricular nucleus , medicine , central nervous system , basal ganglia , globus pallidus
As stressful environment is a potent modulator of feeding, we seek in the present work to decipher the neuroanatomical basis for an interplay between stress and feeding behaviors. For this, we combined anterograde and retrograde tracing with immunohistochemical approaches to investigate the patterns of projections between the dorsomedial division of the bed nucleus of the stria terminalis (BNST), well connected to the amygdala, and hypothalamic structures such as the paraventricular (PVH) and dorsomedial (DMH), the arcuate (ARH) nuclei and the lateral hypothalamic areas (LHA) known to control feeding and motivated behaviors. We particularly focused our study on afferences to proopiomelanocortin (POMC), agouti‐related peptide (AgRP), melanin‐concentrating‐hormone (MCH) and orexin (ORX) neurons characteristics of the ARH and the LHA, respectively. We found light to intense innervation of all these hypothalamic nuclei. We particularly showed an innervation of POMC, AgRP, MCH and ORX neurons by the dorsomedial and dorsolateral divisions of the BNST. Therefore, these results lay the foundation for a better understanding of the neuroanatomical basis of the stress‐related feeding behaviors.